How does Souvenaid work?
Souvenaid – a new nutritional approach in early Alzheimer’s disease
Souvenaid is a medical nutrition product that contains a unique, patented combination of nutrients designed to support synapse formation. Souvenaid represents a new approach to managing early Alzheimer’s disease, addressing the specific nutritional requirements of the patients.
Synapse loss in Alzheimer’s disease
Compared to other hallmarks of Alzheimer’s disease, synapse loss correlates best with impaired memory [1-3]. Synapses are continuously being remodelled, and synapse formation depends on the production of neuronal membranes, which primarily consist of phospholipids [4,5].
Fortasyn Connect™ – providing the nutritional components to support synapse formation
The unique combination of nutritional precursors and cofactors in Souvenaid is known under the name Fortasyn Connect™. These components work together to enhance phospholipid synthesis via the Kennedy pathway [6-16], and include:
specific precursors of phosphatidylcholine, the most abundant phospholipid in the brain:
the long chain omega-3 polyunsaturated fatty acids [PUFAs] (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA])
uridine supplied as uridine monophosphate [UMP]
cofactors that enhance the bioavailability of these precursors:
The increased phospholipid synthesis supports the formation of neuronal membranes . Preclinical models combining these nutritional precursors have demonstrated neurite outgrowth, increased dendritic spines density, increased levels of pre- and post-synaptic proteins, and improved learning [6, 8, 12, 13, 17, 18].
Souvenaid contains a specific combination of nutrients designed to support synapse formation
Key nutritional precursors and co-factors are required for the formation of phosphatidylcholine , which is the key component of neuronal membranes.
This combination of nutrients is required in the Kennedy pathway to form phospholipids
The synthesis of neuronal membranes occurs via the Kennedy pathway which is dependent on the availability of specific nutritional precursors. If any one of these precursors is not available, that specific step in the pathway becomes rate-limiting.Souvenaid - HDIW - Slide 02
The phospholipids are incorporated into neuronal membranes
Phosphatidylcholine is one of the major components of neuronal membranes.
Increased neuronal membrane synthesis supports synapse formation
A new brain synapse is formed when a dendritic spine (postsynaptic structure) interacts with a presynaptic nerve terminal, which is an essential process in neuronal membrane synthesis.
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